Resihance 40 mg (Regorafenib)

Description of resihance 40mg tablet

Resihance 40 mg Tablet contains Resihance 40 mg it’s an antineoplastic and tyrosine kinase inhibitor. It inhibits the signalling process required for the multiplication of abnormal cancer cells. Resihance 40 mg Tablet is used in the treatment of colorectal cancer, hepatocellular carcinoma, and gastrointestinal stromal tumor. This medication is recommended for adults only.

Resihance 40 mg Tablet comes usually in tablet format which is taken once a day according to the doctor’s advice. It is ideally taken in the same time every day. It has been seen that it is usually prescribed to be taken every day for 3 weeks then 1 week gap is given before restarting the dosage.

Side effects are very alarming in some cases when taken without professional guidance. Severe liver toxicity, bleeding, skin-peeling, blood pressure are some of the serious effects. Weakness, fatigue, loss of appetite, diarrhea, weight loss, infections etc are some common side effects which accompany the drug. Hence it must be taken only under Doctor’s advice.

Information given here is based on the salt content of the medicine. Uses and effects of the medicine may vary from person to person. It is advisable to consult a Oncologist before using this medicine.

Resihance 40 mg tablet uses

Resihance 40mg Tablet is used in the treatment of colorectal cancer, GIST and hepatocellular carcinoma. This tablet is used only in adults.

• Cancer Of Colon And Rectum

Colorectal Cancer

This medicine is used to treat metastatic colorectal cancer (cancer that starts either in the colon or rectum) in patients who have not adequately responded to other anticancer medications.

Gastrointestinal stromal tumor

This medicine is used for the treatment of cancer that affects the cells in the wall of the gastrointestinal (GI) tract in patients who failed to respond with other anticancer medicines.

Hepatocellular carcinoma

This medicine is used for the treatment of cancer that affects the liver cells in patients who failed to respond with other anticancer medicines.

How does resihance 40 mg work?

The active constituent of this medicine is a tiny molecule inhibitor of manifold membrane-bound and intracellular kinases associated with normal cellular functions and in pathologic procedures like oncogenesis, tumour angiogenesis, and the retention of the tumour microenvironment.

Regorafenib is an antineoplastic, antiangiogenic and tyrosine kinase inhibitor. It inhibits tyrosine containing intracellular and extracellular receptors thus the signalling process for angiogenesis and proliferation of abnormal cells is inhibited. It minimises the growth of abnormal cancer cells and terminates metastasis of tumors or cancers.

How to take resihance 40 mg tablet ?

This tablet is taken orally; It must be taken at the same time once a day as prescribed by your physician; It must be swallowed as a whole; Don’t chew or crush this tablet.

After therapy has been initiated, do not take more or less of the Regorafenib drug than prescribed or stop taking it without your physicians’ approval. Skipping or changing the Regorafenib dose without approval may cause adverse effects making the condition more difficult to treat, or worsen side effects.

Doses

over dose

Overdosage of this tablet has less literature thus Contact your physician.

Missed dose

You can take the missed dosage if you notice within 12 hours. If it is more than 12 hours, then skip the dosage and take the next doses as usual. Don’t take a double dose for a forgotten dose.

Side effects

Common side effects that occur 1:10 patients: Anemia, Increased AST/ALT, Asthenia, Proteinuria, Hypocalcemia, Hypophosphatemia, Lymphopenia, Decreased appetite and food intake, Increased lipase/amylase, Hyperbilirubinemia, Diarrhea, Thrombocytopenia, Mucositis, Weight loss, Infection, Hypertension, Dysphonia, Hyponatremia, Pain, Fever, Rash, Hypokalemia, Increased INR, Hemorrhage, Nausea, Proteinuria, Alopecia, Hypothyroidism, Neutropenia, Muscle spasms

Rare side effects that occur 1:1,000 patients: Anaphylactic shock, angioedema, urticaria, Stevens-Johnson Syndrome, nephrotic syndrome, cardiac failure, arterial aneurysm/dissection/rupture

General instructions

Resihance 40 mg Tablet is taken orally as prescribed dosage at a specific time regularly with or without food. Do not drink grape juice or eat grapefruit.

 Warnings

• Allergic reactions – It can be mild hypersensitivity and angioedema to severe like Stevens-Johnson Syndrome and toxic epidermal necrolysis.
• Hepatotoxicity
• Secondary infections
• Haemorrhagic disorders
• Gastrointestinal perforation or fistula
• Cardiotoxicity – hypertension/MI
• Reversible Posterior Leukoencephalopathy Syndrome
• Impaired wound healing
• Pregnancy – causes embryo-fetal toxicity
• Breastfeeding – causes side effects similar to adults
• Alcohol intake or Driving or operating heavy machinery – Resihance 40mg Tablet causes side effects thus caution is required. consult your physician

Interactions

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

Leflunomide

Efavirenz

Rosuvastatin

Clarithromycin

Warfarin

Diclofenac

Aspirin

Disease interactions

Lung Toxicity

This medicine should be used with caution in patients with a history of interstitial lung disease presenting with acute onset of new or progressive unexplained pulmonary symptoms such as dyspnea, cough, and fever pending diagnostic evaluation due to the increased risk of the lung toxicity. Appropriate dose adjustments and frequent clinical monitoring are advised in such cases. Replacement with a suitable alternative may be required in some cases based on the clinical condition.

Food interactions

Consumption of grapefruit or grapefruit juice is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.

Lab interactions

Information not available.

This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

Storage and disposal

• Keep the medication out of children’s reach
• Keep the medication away from pets
• Once expired dispose immediately
• Store at 30°C

FAQS:

1.Is Resihance 40 mg chemotherapy?

Yes, Resihance 40 mg is used as a chemotherapy to treat cancer of stomach (gastrointestinal stromal tumors), colon or rectal, in cases who have been treated with other cancer treatments or are incurable with other treatments.

2.How is Resihance 40 mg b administered?

Resihance 40 mg needs to be administered orally as advised by your doctor. It is to be taken at the same time of the day, with food.

3. Does Resihance 40 mg shrink tumors?

Yes, Regorafenib works either by shrinking the tumor or stops it from growing further.

4.Is Resihance 40 mg Tablet safe during pregnancy?

No, taking Resihance 40mg Tablet during pregnancy is not recommended thus inform your physician if you are pregnant or plan to get pregnant

5.Can Resihance 40 mg Tablet be taken while breastfeeding?

No, in general it is suggested that drugs and their metabolites can pass via breastfeeding thus it is suspected that Resihance 40 mg Tablet can also pass via breastfeeding.

6.Can Resihance 40 mg Tablet be taken while alcohol consumption?

The interaction is unknown but this medication causes side effects. Thus, consult your physician.

7.Can I take a drive or operate heavy machineries while on Resihance 40 mg Tablet?

Resihance 40 mg Tablet causes side effects thus caution is used while driving or operating machineries.

8.What kind of food should I avoid while taking Resihance 40 mg Tablet?

Do not take grape juice or eat grape fruits while taking Resihance 40 mg Tablet.